rs77542170
A SNP in the MUTYH gene on chromosome 1. Its most notable genotype is C;C: autosomal recessive familial adenomatous polyposis-2 (FAP2)
- Gene
- MUTYH
- Location
- Chr 145,332,088 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadautosomal recessive familial adenomatous polyposis-2 (FAP2)
- C;TBadCarrier of a colorectal polyposis mutation
- T;TGoodcommon in clinvar
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MUTYH SNPs
- rs34612342C;Cincreased risk for several cancersVery important
- rs36053993T;Tlikely to be at somewhat increased risk for colorectal cancersVery important
- rs200165598C;TPossible polyp associated variant, but of uncertain significanceVery important
- rs1060501342-;CCincreased risk for several cancersVery important
- rs121908380G;TCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
- rs121908381A;CCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
- rs143353451C;TCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
- rs376561094A;GCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
Notes
From SNPedia
Notes
rs77542170, also known as both c.925-2A>G and c.934-2A>G, represents a rare variant in the MUTYH gene on chromosome 1. Inherited recessively, the minor allele is considered in ClinVar (and BabySeq) as a pathogenic mutation for a cancer-predisposing syndrome, autosomal recessive familial adenomatous polyposis-2 (FAP2). Affected individuals have a significantly higher risk of developing colorectal cancer.
C;C
see rs77542170
C;T
Unaffected in absence of another pathogenic MUTYH mutation; see rs77542170
Source and license
Adapted from rs77542170 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.