rs2273535

A SNP in the AURKA gene on chromosome 20. Its most notable genotype is T;T: slightly higher (~1.5x or less) risk for certain cancers

Gene
AURKA
Location
Chr 2056,386,485 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedcommonTypical · 0.040% of people
  2. A;TBadslightly higher (~1.5x or less) risk for certain cancersWorth knowing · 2.039% of people
  3. T;TMost notableBadslightly higher (~1.5x or less) risk for certain cancersWorth knowing · 2.121% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 40% A;T 39% T;T 21%
  • European ancestry (Utah)A;A 69% A;T 26% T;T 5%
  • Han Chinese (Beijing)A;A 13% A;T 47% T;T 40%
  • Japanese (Tokyo)A;A 9% A;T 57% T;T 34%
  • Yoruba (Nigeria)A;A 68% A;T 27% T;T 5%

Conditions, medicines and genes

Other AURKA SNPs

All AURKA SNPs

Notes

From SNPedia

Show notes, about 220 words

SNP rs2273535, also known as F31I or Phe31Ile, has been associated with increased risk for several cancers, in most cases when individuals are homozgyous for the risk allele, rs2273535(T), as oriented to the dbSNP entry. A meta-analysis of almost 10,000 cases of breast, colon, ovarian, prostate, lung, esophageal and non-melanoma skin cancer, compared to an equal number of Caucasian controls, determined the following risks (i.e., odds ratios, OR) : *For colorectal cancer: OR for homozygotes of 1.5 (CI: 1.14-1.99) *For breast cancer: OR for homozygotes of 1.35 (CI: 1.12-1.64) *For any of the cancer types studied: OR for heterozygotes of 1.10 (CI: 1.03-1.18), OR for homozygotes of 1.40 (CI: 1.22-1.59) In a Chinese population, breast cancer risk for rs2273535(T;T) homozygotes compared to the other two genotypes led to an odds ratio of 1.66 (CI: 1.29-2.12), and appeared to be more pronounced for younger patients. However, for lung cancer (among Caucasians), rs2273535(T;T) homozygotes have been reported to be at lower risk; specifically, an odds ratio of 0.63 (CI: 0.41-0.96) has been reported. showed no association with ovarian cancer risk 4,624 invasive epithelial ovarian cancer cases and 8,113 controls of white non-Hispanic origin ovarian cancer

A;T

see discussion at rs2273535

T;T

see discussion at rs2273535

Source and license

Adapted from rs2273535 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.