Lung cancer

53 SNPs linked to Lung cancer across 35 genes, 22 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 53
Notable: 22Magnitude 2 or higher
Well documented: 40
Genes: 35

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs45446698ZSCAN25Important
- T;Tcommon/normalGood
- G;TCarrier of a CYP3A7*1C allele; possibly reduced contraceptive effectiveness and slightly increased cancer riskBad
- G;GCarrier of two CYP3A7*1C alleles; possibly reduced contraceptive effectiveness and moderately increased cancer riskBad
rs4986782NAT1Important
- A;Aslow acetylator = higher risk of smoking-induced lung cancerBad
- A;Gslow acetylator = higher risk of smoking-induced lung cancerBad
- G;Gcommon in complete genomicsGood
rs6983267CASC8Important
- G;G1.6x increased risk for prostate cancer; also other cancersBad
- G;T1.3x risk of prostate cancer; aspirin reduces risk of colorectal cancerBad
- T;Tnormal risk for cancers; aspirin reduces risk for colorectal cancerGood
rs1800566NQO1Important
- G;Gcommon in clinvarGood
- A;GPossible Lower Lung Cancer riskGood
- A;ABenzene toxicity; cancer risksBad
rs1042522TP53Important
- G;GLive 3 years longer. Chemotherapy is more effective.Good
- C;GSlightly increased lifespan?Good
- C;CCommon variant. Slightly shorter lifespan.Bad
rs16969968CHRNA5Important
- A;Ahigher risk for nicotine dependence, lower risk for cocaine dependenceBad
- A;Gslightly higher risk for nicotine dependence, lower risk for cocaine dependenceBad
- G;GnormalNot rated
rs1801133MTHFRWorth knowing
- G;GCommon genotype: normal homocysteine levelsGood
- A;G1 copy of C677T allele of MTHFR = 65% efficiency in processing folic acidBad
- A;Ahomozygous for C677T of MTHFR = 10-20% efficiency in processing folic acid = high homocysteine, low B12 and folate levelsBad
rs663048SEZ6LWorth knowing
- G;GNormal risk of developing lung cancerGood
- G;TSignificantly increased risk of developing lung cancerBad
- T;T3x increased risk of developing lung cancerBad
rs664143ATMWorth knowing
- G;GnormalNot rated
- A;GHigher risk for number of cancersBad
- A;AHigher risk for number of cancersBad
rs1051730CHRNA3Worth knowing
- G;GSmokes normal (lower) number of cigarettes if a smoker.Good
- A;G1.3x increased risk of lung cancerBad
- A;A1.8x increased risk of lung cancer; reduced response to alcohol, therefore possibly increased risk of alcohol abuseBad
rs1052133OGG1Worth knowing
- C;CnormalGood
- C;Gnormal for bladder cancer risk; 1.9x increased risk for gallbladder cancerBad
- G;G2x increased bladder cancer risk; 4.5x increased risk for gallbladder cancerBad
rs2273535AURKAWorth knowing
- A;AcommonNot rated
- A;Tslightly higher (~1.5x or less) risk for certain cancersBad
- T;Tslightly higher (~1.5x or less) risk for certain cancersBad
rs2279744MDM2Worth knowing
- G;GGenerally more cancer proneBad
- G;TSlightly more cancer prone; commonBad
- T;TnormalGood
rs17576MMP9Worth knowing
- A;Anormal risk for lung cancer; higher risk for MINot rated
- A;Ghigher risk for MI and lung cancer, and COPD in smokersBad
- G;Ghigher risk for lung cancer, and COPD in smokers; normal risk for MIBad
rs25487XRCC1Worth knowing
- T;T0.7x lower risk for skin cancerGood
- C;T2x higher risk for skin cancer; possibly other cancersBad
- C;C2x higher risk for skin cancer; possibly other cancersBad
rs31489CLPTM1LWorth knowing
- A;AReduced lung cancer risk?Not rated
- A;C1.75-fold reduced risk of developing lung cancerGood
- C;CIncreased risk for lung cancer and emphysemaBad
rs1056836CYP1B1Worth knowing
- G;GnormalNot rated
- C;GnormalNot rated
- C;C0.3x decreased risk for prostate cancerGood
rs1169300HNF1AWorth knowing
- A;A~2x increased lung cancer riskBad
- A;G~1.5x increased lung cancer riskBad
- G;GnormalNot rated
rs2352028GPC5Worth knowing
- C;CNo summary available.Not rated
- C;TNo summary available.Bad
- T;TIncreased risk of lung cancer in non-smokers and never smokersBad
rs2464196HNF1AWorth knowing
- G;GnormalGood
- A;G~1.5x increased lung cancer riskBad
- A;A~2x increased lung cancer riskBad
rs3117582APOMWorth knowing
- T;Tcommon on affy axiom dataGood
- G;Gincreased lung cancer riskBad
rs11614913MIR196A2Worth knowing
- C;CSomewhat increased risk of various types of cancerBad
- C;TnormalNot rated
- T;Tdecreased risk for colorectal cancer and lung cancerGood
rs401681CLPTM1LMinor
- C;C~1.2x increased risk for several types of cancerBad
- C;T~1.2x increased risk for several types of cancerBad
- T;TnormalNot rated
rs1892534Minor
- T;TLower C-Reactive Protein levels. 1.2x increased risk overall for cancers.Bad
- C;TNormal C-Reactive Protein levels. Very slight (x1.05) increase in overall risk for cancers.Not rated
- C;CSlightly higher C-Reactive Protein levels. Possibly slightly lower cancer risk.Good
rs2032582ABCB1Minor
- T;Trare genotype, on a triallelic snpGood
- C;Cnormal. better response to atorvastatin. greater severity of delusions in male schizophrenics.Bad
- A;A4x higher risk for lung cancerBad
rs748404TGM5Minor
- C;CNo summary available.Not rated
- C;Tvery slightly increased risk (1.15) for lung cancerBad
- T;Tslightly increased risk (1.25) for lung cancerBad
rs12050604UBR1Minor
- A;Aslightly increased risk for lung cancerBad
- A;Cvery slightly increased risk for lung cancerBad
- C;CNo summary available.Not rated
rs3842ABCB1Typical
- T;TNo summary available.Not rated
rs193008SLC44A1Typical
- T;Tcommon in complete genomicsGood
rs763317EGFRTypical
- A;A3.5x increased lung cancer risk for never-smoking femalesNot rated
- A;Gincreased lung cancer risk for never-smoking femalesNot rated
- G;GnormalNot rated
rs1801270CDKN1ATypical
- A;Aincreased risk for lung cancerBad
- A;Cincreased risk for lung cancerBad
- C;Cnormal riskGood
rs2066853AHRTypical
- G;GNo summary available.Not rated
rs2228001XPCTypical
- T;TNo summary available.Not rated
- G;TnormalNot rated
- G;GnormalGood
rs2228014CXCR4Typical
- G;Gcommon on affy axiom dataGood
rs2250889MMP9Typical
- C;C1.69x higher risk for lung cancerBad
- C;G1.46x higher risk for lung cancerBad
- G;Gnormal riskGood
rs2308327MGMTTypical
- A;AnormalBad
- A;G0.67x decreased risk for lung cancerGood
- G;G0.10x decreased risk for lung cancerGood
rs2333227MPOTypical
- C;CNo summary available.Not rated
- C;T0.8x decreased risk for lung cancer among smokers; increased gastric cancer riskNot rated
- T;T0.7x decreased risk for lung cancer among smokers; increased gastric cancer riskNot rated
rs3750861KLF6Typical
- C;Ccommon in complete genomicsGood
rs8178085PRKDCTypical
- T;Tcommon in complete genomicsGood
rs17879961CHEK2Typical
- T;TNo summary available.Not rated
- A;Acommon in clinvarGood

Other SNPs

No notable genotype or detailed notes

Show 13 SNPs

Source and license

Adapted from Lung cancer on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.

Linked SNPs

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Genes

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Source and license