rs664143

A SNP in the ATM gene on chromosome 11. Its most notable genotype is A;G: Higher risk for number of cancers

Gene
ATM
Location
Chr 11108,354,934 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
40%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GNot ratednormalTypical · 0.037% of people
  2. A;GMost notableBadHigher risk for number of cancersWorth knowing · 2.544% of people
  3. A;ABadHigher risk for number of cancersWorth knowing · 2.519% of people

SNPedia records rs664143 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 37% A;G 44% A;A 19%
  • European ancestry (Utah)G;G 27% A;G 54% A;A 19%
  • Han Chinese (Beijing)G;G 23% A;G 44% A;A 34%
  • Japanese (Tokyo)G;G 24% A;G 42% A;A 35%
  • Yoruba (Nigeria)G;G 46% A;G 48% A;A 6%
  • African ancestry (Southwest US)G;G 56% A;G 30% A;A 14%
  • Chinese (Denver)G;G 21% A;G 51% A;A 28%
  • Gujarati IndianG;G 52% A;G 39% A;A 10%
  • Luhya (Kenya)G;G 41% A;G 47% A;A 12%
  • Mexican ancestry (Los Angeles)G;G 38% A;G 41% A;A 21%
  • Maasai (Kenya)G;G 27% A;G 50% A;A 23%
  • TuscanG;G 55% A;G 33% A;A 12%

Conditions, medicines and genes

Other ATM SNPs

All ATM SNPs

Notes

From SNPedia

Show notes, about 150 words

600+ Korean lung cancer patients were part of a study that concluded that the rs664143(T) allele, as oriented vis-a-vis dbSNP, located in the ATM gene and also known as IVS62+60G>A, was associated with increased risk, with an odds ratio of 1.68 (CI: 1.1-2.1, p<0.05). In a study of 119 American patients with potentially resectable pancreatic cancer, the rs664143(C) allele was associated with poorer overall survival (ie response) to combined gerncitabine radiation therapy. Also, as 1 of 3 SNPs its risk allele is associated with poorer overall survival for pancreatic cancer patients being treated with combined gerncitabine radiation therapy; median overall survival times of 31.0, 16.2, and 10.5 months were calculated for pancreatic cancer patients carrying < or = 1, 2, and 3 risk alleles from rs664143(C), rs2227928(C), and rs521102(T;T), respectively (P=0.004).

Source and license

Adapted from rs664143 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.