rs2352028

A SNP in the GPC5 gene on chromosome 13. Its most notable genotype is C;T.

Gene
GPC5
Location
Chr 1391,792,975 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratedNo summary available.Typical · 0.040% of people
  2. C;TMost notableBadNo summary available.Worth knowing · 2.042% of people
  3. T;TBadIncreased risk of lung cancer in non-smokers and never smokersWorth knowing · 2.018% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 40% C;T 42% T;T 18%
  • European ancestry (Utah)C;C 58% C;T 35% T;T 6%
  • Han Chinese (Beijing)C;C 50% C;T 43% T;T 7%
  • Japanese (Tokyo)C;C 38% C;T 53% T;T 9%
  • Yoruba (Nigeria)C;C 16% C;T 45% T;T 40%
  • African ancestry (Southwest US)C;C 18% C;T 54% T;T 28%
  • Chinese (Denver)C;C 63% C;T 33% T;T 4%
  • Gujarati IndianC;C 75% C;T 21% T;T 4%
  • Luhya (Kenya)C;C 17% C;T 51% T;T 32%
  • Mexican ancestry (Los Angeles)C;C 40% C;T 45% T;T 16%
  • Maasai (Kenya)C;C 13% C;T 44% T;T 44%
  • TuscanC;C 56% C;T 33% T;T 11%

Conditions, medicines and genes

Other GPC5 SNPs

All GPC5 SNPs

Notes

From SNPedia

Notes

news increased risk of lung cancer in non smokers. Analysis showed that the presence of this variant significantly increased the risk of a never smoker having lung cancer by 1.46 times (odds ratio 1.46, 95% confidence interval 1.26 to 1.70).

Source and license

Adapted from rs2352028 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.