rs763317
A SNP in the EGFR gene on chromosome 7. Its most notable genotype is A;A: 3.5x increased lung cancer risk for never-smoking females
- Gene
- EGFR
- Location
- Chr 755,027,504 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 35%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot rated3.5x increased lung cancer risk for never-smoking females
- A;GNot ratedincreased lung cancer risk for never-smoking females
- G;GNot ratednormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 12% A;G 43% G;G 45%
- European ancestry (Utah)A;A 20% A;G 44% G;G 36%
- Han Chinese (Beijing)A;A 4% A;G 33% G;G 63%
- Japanese (Tokyo)A;A 3% A;G 33% G;G 65%
- Yoruba (Nigeria)A;A 12% A;G 45% G;G 43%
- African ancestry (Southwest US)A;A 16% A;G 40% G;G 44%
- Chinese (Denver)A;A 6% A;G 42% G;G 52%
- Gujarati IndianA;A 20% A;G 42% G;G 39%
- Luhya (Kenya)A;A 6% A;G 46% G;G 49%
- Mexican ancestry (Los Angeles)A;A 9% A;G 45% G;G 47%
- Maasai (Kenya)A;A 9% A;G 55% G;G 37%
- TuscanA;A 31% A;G 49% G;G 20%
Related
Conditions, medicines and genes
Other EGFR SNPs
- rs2293347C;Camong NSCLC patients, better Gefitinib response; commonMinor
- rs1050171G;Gcommon in clinvarTypical
- rs2072454C;Ccommon in clinvarTypical
- rs2227983G;Gcommon in clinvarTypical
- rs3735061G;Gcommon in complete genomicsTypical
- rs6958497T;Tcommon in complete genomicsTypical
- rs11979158A;Acommon in complete genomicsTypical
- rs17290699A;Acommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs763317, also known as 8227A>G, is a SNP located in the first intron of the epidermal growth factor receptor EGFR gene. In a study of 730 Taiwanese patients with lung cancer and matched controls, never-smoking females having at least one rs763317(A) allele were at increased risk (p = 0.009) for adenocarcinomas; the adjusted odds ratio for the (A;G) genotype was 1.23, CI: 0.87-1.75, and for the (A;A) genotype, the odds ratio was 3.52, CI: 1.32-9.37.
Source and license
Adapted from rs763317 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.