rs2072454
A SNP in the EGFR gene on chromosome 7. Its most notable genotype is C;C: common in clinvar
- Gene
- EGFR
- Location
- Chr 755,146,655 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 45%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 29%
- European ancestry (Utah)C;C 21%
- Han Chinese (Beijing)C;C 31%
- Japanese (Tokyo)C;C 46%
- Yoruba (Nigeria)C;C 27%
- African ancestry (Southwest US)C;C 25%
- Chinese (Denver)C;C 35%
- Gujarati IndianC;C 14%
- Luhya (Kenya)C;C 38%
- Mexican ancestry (Los Angeles)C;C 26%
- Maasai (Kenya)C;C 28%
- TuscanC;C 29%
Related
Other EGFR SNPs
- rs2293347C;Camong NSCLC patients, better Gefitinib response; commonMinor
- rs763317A;A3.5x increased lung cancer risk for never-smoking femalesTypical
- rs1050171G;Gcommon in clinvarTypical
- rs2227983G;Gcommon in clinvarTypical
- rs3735061G;Gcommon in complete genomicsTypical
- rs6958497T;Tcommon in complete genomicsTypical
- rs11979158A;Acommon in complete genomicsTypical
- rs17290699A;Acommon in complete genomicsTypical
Source and license
Adapted from rs2072454 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.