rs2250889

A SNP in the MMP9 gene on chromosome 20. Its most notable genotype is C;C: 1.69x higher risk for lung cancer

Gene
MMP9
Location
Chr 2046,013,767 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
15%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.69x higher risk for lung cancerTypical · 0.064% of people
  2. C;GBad1.46x higher risk for lung cancerTypical · 0.032% of people
  3. G;GGoodnormal riskTypical · 0.04% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 64% C;G 32% G;G 4%
  • European ancestry (Utah)C;C 91% C;G 9% G;G 0%
  • Han Chinese (Beijing)C;C 51% C;G 42% G;G 7%
  • Japanese (Tokyo)C;C 46% C;G 46% G;G 9%
  • Yoruba (Nigeria)C;C 70% C;G 30% G;G 0%

Conditions, medicines and genes

Other MMP9 SNPs

All MMP9 SNPs

Notes

From SNPedia

Notes

rs2250889, a SNP also known as P574R, is located in the MMP9 gene. In a study of 744 Chinese patients with incident lung cancer rs2250889(C;G) heterozygotes and rs2250889(C;C) homozygotes had 1.46-fold (CI: 0.94-2.26) and 1.69-fold elevated risk (CI: 1.10-2.60) for lung cancer, respectively, compared with the (G;G) genotype. There was an additive effect of having additional MMP9 risk alleles.

C;C

appears to be common on the 23andMe platform

Source and license

Adapted from rs2250889 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.