rs17577

A SNP in the MMP9 gene on chromosome 20. Its most notable genotype is G;G: common in clinvar

Gene
MMP9
Location
Chr 2046,014,472 (GRCh38)
Highest magnitude
0.0Typical
Tested on
Not on consumer chips
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.069% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 69%
  • European ancestry (Utah)G;G 71%
  • Han Chinese (Beijing)G;G 75%
  • Japanese (Tokyo)G;G 66%
  • Yoruba (Nigeria)G;G 65%
  • African ancestry (Southwest US)G;G 70%
  • Chinese (Denver)G;G 81%
  • Gujarati IndianG;G 46%
  • Luhya (Kenya)G;G 70%
  • Mexican ancestry (Los Angeles)G;G 76%
  • Maasai (Kenya)G;G 61%
  • TuscanG;G 74%

Other MMP9 SNPs

All MMP9 SNPs

Notes

From SNPedia

Show notes, about 250 words

Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease. Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma. Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools. Matrix metalloproteinase-3 genotypes influence recovery from hepatitis B virus infection. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk. Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population. MMP-9 gene variants increase the risk for non-atopic asthma in children. Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals. Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis. MMP9 polymorphisms and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study. Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia. Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.

Source and license

Adapted from rs17577 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.