rs2228014

A SNP in the CXCR4 gene on chromosome 2. Its most notable genotype is G;G: common on affy axiom data

Gene
CXCR4
Location
Chr 2136,115,514 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
6%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon on affy axiom dataTypical · 0.086% of people

SNPedia records rs2228014 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 3 HapMap populations.

  • AverageG;G 86%
  • Han Chinese (Beijing)G;G 76%
  • Japanese (Tokyo)G;G 86%
  • Yoruba (Nigeria)G;G 95%

Conditions, medicines and genes

Notes

From SNPedia

Notes

the TT genotype increased 6.5X risk of lung cancer compared with CC genotype in chinese.

Source and license

Adapted from rs2228014 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.