rs1892534

A SNP on chromosome 1. Its most notable genotype is C;C: Slightly higher C-Reactive Protein levels. Possibly slightly lower cancer risk.

Gene
None listed
Location
Chr 165,640,261 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
45%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TBadLower C-Reactive Protein levels. 1.2x increased risk overall for cancers.Minor · 1.237% of people
  2. C;TNot ratedNormal C-Reactive Protein levels. Very slight (x1.05) increase in overall risk for cancers.Minor · 1.139% of people
  3. C;CMost notableGoodSlightly higher C-Reactive Protein levels. Possibly slightly lower cancer risk.Minor · 1.524% of people

SNPedia records rs1892534 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 37% C;T 39% C;C 24%
  • European ancestry (Utah)T;T 12% C;T 44% C;C 45%
  • Han Chinese (Beijing)T;T 79% C;T 21% C;C 0%
  • Japanese (Tokyo)T;T 80% C;T 20% C;C <1%
  • Yoruba (Nigeria)T;T 24% C;T 52% C;C 24%
  • African ancestry (Southwest US)T;T 33% C;T 40% C;C 26%
  • Chinese (Denver)T;T 77% C;T 22% C;C <1%
  • Gujarati IndianT;T 21% C;T 49% C;C 31%
  • Luhya (Kenya)T;T 14% C;T 52% C;C 35%
  • Mexican ancestry (Los Angeles)T;T 36% C;T 40% C;C 24%
  • Maasai (Kenya)T;T 14% C;T 47% C;C 40%
  • TuscanT;T 16% C;T 44% C;C 40%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 210 words

rs1892534 is a SNP that was originally associated with C-reactive protein levels, and given other findings that suggest C-reactive protein levels may be predictive of cancer risk, was thought to be linked to cancer risk. A large study pooling data from 3 Finnish studies totaling over 18,000 individuals concluded that while the rs1892534(A) allele was not likely to be causative (relative to cancer), it is associated with increased risk for cancer overall. The odds ratio for 1 or 2 such alleles was 1.05 (CI: 0.90 - 1.23) and 1.2 (CI: 1.01 - 1.42) overall. Two other CRP SNPs (rs1169300 and rs2464196) were specifically associated with increased lung cancer risk. CRP SNPs were not associated with colorectal, prostate or breast cancer risk.

T;T

This causes a lower median hsCRP Level of 1.40 mg/L in women. PMID 18439548PMID 21647738 Strangely this was associated with a higher overall cancer risk (in Finnish people). PMID 20727736

C;T

This causes a median hsCRP Level of 1.88 mg/L in women. PMID 18439548PMID 21647738 Strangely this was associated with a slightly higher overall cancer risk (in Finnish people). PMID 20727736

C;C

This causes a median hsCRP Level of 2.09 mg/L in women. Strangely this was associated with a slightly lower overall cancer risk (in Finnish people).

References

Source and license

Adapted from rs1892534 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.