rs1052133

A SNP in the OGG1 gene on chromosome 3. Its most notable genotype is G;G: 2x increased bladder cancer risk; 4.5x increased risk for gallbladder cancer

Gene
OGG1
Location
Chr 39,757,089 (GRCh38)
Highest magnitude
2.2Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.045% of people
  2. C;GBadnormal for bladder cancer risk; 1.9x increased risk for gallbladder cancerWorth knowing · 2.140% of people
  3. G;GMost notableBad2x increased bladder cancer risk; 4.5x increased risk for gallbladder cancerWorth knowing · 2.214% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 45% C;G 40% G;G 14%
  • European ancestry (Utah)C;C 65% C;G 29% G;G 6%
  • Han Chinese (Beijing)C;C 24% C;G 51% G;G 24%
  • Japanese (Tokyo)C;C 18% C;G 59% G;G 23%
  • Yoruba (Nigeria)C;C 74% C;G 23% G;G 3%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 180 words

rs1052133, also known as Ser326Cys, is a SNP in the oxoguanine glycosylase 1 OGG1 gene, involved in the repair of DNA damage (for example, damage caused by tobacco smoke). The minor (rarer) allele, encoding the cysteine (Cys), is rs1052133(G). Note that associations reported for this SNP are not always replicating in different studies or populations. A study of 250 Japanese patients with bladder cancer found an adjusted odds ratio of 2.05 (CI: 1.36-3.08; p = 0.01) for (G;G) homozygotes compared to the other genotypes. In addition, if evaluated only in non-smokers, the adjusted odds ratio increased to 2.78 (CI: 1.39-5.60; p < 0.01). A study of 200 Chinese patients with gallbladder cancer concluded that increased risk was associated with both the (C;G) genotype (odds ratio 1.9, (CI: = 1.0-3.7) and the (G;G) genotype (odds ratio 4.5, CI: 1.1-22.4). A study of 300 lung cancer patients of various ethnicities found that the (G;G) genotype was associated with an odds ratio of 2.1 (CI: 1.2-3.7), regardless of sex or ethnicity. However, a Danish study of 400 lung cancer patients found no association.

Source and license

Adapted from rs1052133 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.