rs3117582

A SNP in the APOM gene on chromosome 6. Its most notable genotype is G;G: increased lung cancer risk

Gene
APOM
Location
Chr 631,652,743 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
4%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon on affy axiom dataTypical · 0.094% of people
  2. G;GMost notableBadincreased lung cancer riskWorth knowing · 2.0<1% of people

SNPedia records rs3117582 on the minus strand: (A;A), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageT;T 94% G;G <1%
  • European ancestry (Utah)T;T 85% G;G <1%
  • Han Chinese (Beijing)T;T 100% G;G 0%
  • Japanese (Tokyo)T;T 100% G;G 0%
  • Yoruba (Nigeria)T;T 93% G;G <1%
  • African ancestry (Southwest US)T;T 95% G;G 0%
  • Luhya (Kenya)T;T 97% G;G 0%
  • Mexican ancestry (Los Angeles)T;T 95% G;G 0%
  • Maasai (Kenya)T;T 90% G;G 0%
  • TuscanT;T 87% G;G 0%

Conditions, medicines and genes

Other APOM SNPs

All APOM SNPs

Notes

From SNPedia

Notes

lung cancer rs3117582 P = 4.97 x 10(-10) Update in lung cancer 2008. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers.

Source and license

Adapted from rs3117582 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.