rs2308327
A SNP in the MGMT gene on chromosome 10. Its most notable genotype is A;A: normal
- Gene
- MGMT
- Location
- Chr 10129,766,906 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 6%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadnormal
- A;GGood0.67x decreased risk for lung cancer
- G;GGood0.10x decreased risk for lung cancer
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 93% A;G 7% G;G <1%
- European ancestry (Utah)A;A 70% A;G 29% G;G <1%
- Han Chinese (Beijing)A;A 99% A;G <1% G;G 0%
- Japanese (Tokyo)A;A 100% A;G 0% G;G 0%
- Yoruba (Nigeria)A;A 100% A;G 0% G;G 0%
- African ancestry (Southwest US)A;A 95% A;G 5% G;G 0%
- Chinese (Denver)A;A 98% A;G 2% G;G 0%
- Gujarati IndianA;A 90% A;G 9% G;G 1%
- Luhya (Kenya)A;A 99% A;G <1% G;G 0%
- Mexican ancestry (Los Angeles)A;A 95% A;G 5% G;G 0%
- Maasai (Kenya)A;A 99% A;G <1% G;G 0%
- TuscanA;A 78% A;G 22% G;G 0%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 140 words
rs2308327, also known as K178R, is a SNP in the MGMT gene. The more common allele, rs2308327(A), encodes a lysine (K) at codon 178, while the (G) allele encodes an arginine (R). In a pooled analysis of 200+ lung cancer patients, the rs2308327(G) allele was reported to provide a protective effect against lung cancer, and furthermore, more (G) alleles meant more protection, particularly for smokers. The odds ratios reported (p=0.003) were 0.67 (CI: 0.45-1.01) for heterozygotes, and 0.10 (CI: 0.01-0.94) for rs2308327(G;G) homozygotes. In a study of 300+ colon cancer cases, rs2308327(G), in linkage disequilibrium with the previously reported MGMT Ile(143)Val rs2308321 SNP, had an inverse association with colorectal cancer risk (odds ratio 0.52, CI: 0.35-0.78, unadjusted p(trend) = 0.0003 for the additive model).
Source and license
Adapted from rs2308327 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.