rs16906252

A SNP in the MGMT gene on chromosome 10. Its most notable genotype is T;T.

Gene
MGMT
Location
Chr 10129,467,281 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
3%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedNo summary available.Worth knowing · 2.0
  2. G;GNot ratedNo summary available.Typical · 0.0
  3. C;CGoodcommon/normalTypical · 0.0

SNPedia records rs16906252 on the minus strand: (A;A), (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other MGMT SNPs

All MGMT SNPs

Notes

From SNPedia

Notes

strongly associated with MGMT methylation (multivariate odds ratio 18.0; 95% confidence interval, 6.2-52.1, P < 0.0001) and loss of MGMT expression in colorectal cancer tumors

T;T

rs16906252(T) is a key determinant in the onset of MGMT methylation in colorectal cancer.

References

Source and license

Adapted from rs16906252 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.