rs2308321

A SNP in the MGMT gene on chromosome 10. Its most notable genotype is A;A: common in complete genomics

Gene
MGMT
Location
Chr 10129,766,800 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
6%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon in complete genomicsTypical · 0.093% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 93%
  • European ancestry (Utah)A;A 69%
  • Han Chinese (Beijing)A;A 99%
  • Japanese (Tokyo)A;A 100%
  • Yoruba (Nigeria)A;A 100%
  • African ancestry (Southwest US)A;A 95%
  • Chinese (Denver)A;A 98%
  • Gujarati IndianA;A 90%
  • Luhya (Kenya)A;A 99%
  • Mexican ancestry (Los Angeles)A;A 95%
  • Maasai (Kenya)A;A 99%
  • TuscanA;A 78%

Other MGMT SNPs

All MGMT SNPs

Notes

From SNPedia

Notes

rs2308321, also known as Ile143Val or I143V, is a SNP in the MGMT gene. The more common (A) allele encodes the Ile, while the (G) allele encodes the Val. This change at codon 143 is often reported to be linked to a change at codon 178, rs2308327.

Source and license

Adapted from rs2308321 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.