rs4986782

A SNP in the NAT1 gene on chromosome 8. Its most notable genotype is A;A: slow acetylator = higher risk of smoking-induced lung cancer

Gene
NAT1
Location
Chr 818,222,607 (GRCh38)
Highest magnitude
3.5Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadslow acetylator = higher risk of smoking-induced lung cancerImportant · 3.50% of people
  2. A;GBadslow acetylator = higher risk of smoking-induced lung cancerImportant · 3.2<1% of people
  3. G;GGoodcommon in complete genomicsTypical · 0.099% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 5 HapMap populations.

  • AverageA;A 0% A;G <1% G;G 99%
  • European ancestry (Utah)A;A 0% A;G 3% G;G 97%
  • Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
  • Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • TuscanA;A 0% A;G 1% G;G 99%

Conditions, medicines and genes

Other NAT1 SNPs

All NAT1 SNPs

Notes

From SNPedia

Notes

NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma.

A;A

(rs4986782; 560G>A; R187Q). NAT1*14B is associated with higher frequency of smoking-induced lung cancer and is the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant

A;G

associated with higher frequency of smoking-induced lung cancer and is the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant

References

Source and license

Adapted from rs4986782 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.