rs1800566

A SNP in the NQO1 gene on chromosome 16. Its most notable genotype is A;A: Benzene toxicity; cancer risks

Gene
NQO1
Location
Chr 1669,711,242 (GRCh38)
Highest magnitude
3.1Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.052% of people
  2. A;GGoodPossible Lower Lung Cancer riskMinor · 1.839% of people
  3. A;AMost notableBadBenzene toxicity; cancer risksImportant · 3.110% of people

SNPedia records rs1800566 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 52% A;G 39% A;A 10%
  • European ancestry (Utah)G;G 66% A;G 32% A;A 3%
  • Han Chinese (Beijing)G;G 29% A;G 55% A;A 17%
  • Japanese (Tokyo)G;G 37% A;G 51% A;A 12%
  • Yoruba (Nigeria)G;G 69% A;G 28% A;A 3%
  • African ancestry (Southwest US)G;G 63% A;G 32% A;A 5%
  • Chinese (Denver)G;G 28% A;G 50% A;A 23%
  • Gujarati IndianG;G 40% A;G 42% A;A 19%
  • Luhya (Kenya)G;G 65% A;G 35% A;A <1%
  • Mexican ancestry (Los Angeles)G;G 45% A;G 40% A;A 16%
  • Maasai (Kenya)G;G 69% A;G 26% A;A 5%
  • TuscanG;G 59% A;G 35% A;A 6%

Conditions, medicines and genes

Other NQO1 SNPs

All NQO1 SNPs

Notes

From SNPedia

Notes

rs1800566 (C609T, Pro187Ser) is a snp within NQO1 (NAD(P)H dehydrogenase (quinone 1)). A Ser (T) at this location denotes the NQO1*2 allele. influences the risk of breast cancer according to the 23andMe blog rs1800566(C;T) heterozygotes have 0.48x reduced risk for Lung cancer

A;G

rs1800566 may decrease susceptibility to Lung Cancer 0.48 times for heterozygotes (CT) due to the presence of the T allele reducing the rate at which the pro-carcinogenic activating NOD1 enzyme operates PMID 15498787

A;A

susceptibility to Leukemia, post-chemotherapy, susceptibility to Breast cancer

References

Source and license

Adapted from rs1800566 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.