rs1131341

A SNP in the NQO1 gene on chromosome 16. Its most notable genotype is G;G.

Gene
NQO1
Location
Chr 1669,714,966 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
2%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedNo summary available.Typical · 0.095% of people

SNPedia records rs1131341 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 95%
  • European ancestry (Utah)G;G 93%
  • Han Chinese (Beijing)G;G 95%
  • Japanese (Tokyo)G;G 94%
  • Yoruba (Nigeria)G;G 99%

Other NQO1 SNPs

All NQO1 SNPs

Notes

From SNPedia

Notes

rs1131341 (C465T, Arg139Trp) is a snp within NQO1 (NAD(P)H dehydrogenase (quinone 1)). A Trp (T) at this location denotes the NQO1*3 allele. per http://www.pharmgkb.org/views/reports/loadVariantReport.action?variantPositionId=6740972#tabview=tab1 pharmgkb, the NQ1*3 allele is associated with reduced enzyme activity T allele strongly associated (OR = 6.36, CI = 1.84 - 21.90, p = 0.002) with infant acute lymphoblastic leukemia among 103 case infants and 185 controls

Source and license

Adapted from rs1131341 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.