rs2032582

A SNP in the ABCB1 gene on chromosome 7. Its most notable genotype is T;T: rare genotype, on a triallelic snp

Gene
ABCB1
Location
Chr 787,531,302 (GRCh38)
Highest magnitude
1.5Minor
Tested on
AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodrare genotype, on a triallelic snpMinor · 1.50% of people
  2. C;CBadnormal. better response to atorvastatin. greater severity of delusions in male schizophrenics.Minor · 1.042% of people
  3. A;ABad4x higher risk for lung cancerMinor · 1.518% of people

SNPedia records rs2032582 on the minus strand: (A;A), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageT;T 0% C;C 42% A;A 18%
  • European ancestry (Utah)T;T 0% C;C 26% A;A 20%
  • Han Chinese (Beijing)T;T 0% C;C 20% A;A 29%
  • Japanese (Tokyo)T;T 0% C;C 22% A;A 31%
  • African ancestry (Southwest US)T;T 0% C;C 81% A;A 2%
  • Chinese (Denver)T;T 0% C;C 19% A;A 22%
  • Gujarati IndianT;T 0% C;C 9% A;A 41%
  • Luhya (Kenya)T;T 0% C;C 96% A;A 0%
  • Mexican ancestry (Los Angeles)T;T 0% C;C 29% A;A 14%
  • Maasai (Kenya)T;T 0% C;C 83% A;A <1%
  • TuscanT;T 0% C;C 34% A;A 20%

Conditions, medicines and genes

Other ABCB1 SNPs

All ABCB1 SNPs

Notes

From SNPedia

Show notes, about 210 words

rs2032582, also known as G2677T, is a nonsynonymous SNP located in exon 21 of the ABCB1 gene. G2677 is also known as Ala893Thr. It is often studied in conjunction with rs1045642. The rs2032582(T) variant allele yields a 2.6 fold higher risk of developing lung cancer, and in particular, the type of lung cancer called squamous cell carcinoma (CI 1.7-4.0, P 150 mg/day) and lower (< or =150 mg/day) methadone dose groups differed significantly in their rs1128503 status (experiment-wise p = 0.0325). Furthermore, individuals with the 3-locus genotype pattern (T;T)-(T;T)-(T;T) for SNPs rs1045642, rs2032582 and rs1128503, respectively, had an approximately 5-fold chance of requiring the 'higher' methadone dose, while individuals heterozygous for these three SNPs have an approximately 3-fold chance of stabilizing at the 'lower' methadone dose (point-wise p-value = 0.026). OMIM also reports an association with Crohn's disease.

C;C

Association study between the MDR1 gene and clinical characteristics in schizophrenia. (2014). Male schizophrenic carriers of the G allele of variant rs2032582 exhibit greater severity of delusions.

A;A

no clear consensus on its significance for drug disposition, response or toxicity, but those are the sorts of effects it appears to influence.

Source and license

Adapted from rs2032582 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.