rs2032583

rs2032583 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and their efficacy or potential for adverse side effects. Clinical studies on antidepressant drug dosage, plasma medication levels and treatment outcome suggest monotonic associations for tricyclic antidepressant drugs and threshold models or higher order relationships for selective serotonin reuptake inhibitors and newer antidepressant drugs ,. However, the link between the increased brain concentrations of antidepressants and a clinically significant response is to be confirmed. A study of ~400 of German psychiatric inpatients with depression conducted in 2007 by Uhr et al found that rs2032583(C) carriers treated with ABCB1 substrates had better chances on remission. However,could not be reproduced in a large (~900) -trial with outpatient with major depression treated with the ABCB1 substrate citalopram (STAR-D study, level 1). According to a recent meta analysis , the significant association of antidepressant treatment outcome among all studies with this SNP becomes insignificant after Bonferroni correction for multiple comparisons. However, the association remained significant after Bonferroni-correction in a subgroup-analysis of all inpatients. rs2032583 is one of 9 SNPs found within a tight linkage block (r 2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The 9 SNPs in the linkage block identified are : * rs2235067 * rs4148740 * rs2032583 * rs4148739 * rs11983225 * rs2235040 * rs12720067 * rs7787082 * rs10248420 In contrast, reported on two SNPs from the block, rs2032583 and rs2235040, that these SNPs are close to Hardy–Weinberg equilibrium (not inherited together) in their 81% white population. Other results from are unreliable because they picked an antidepressant sertraline, which is, likely, not an ABCB1 substrate , as an example of an ABCB1 substrate and treated a majority of patients in the study with it. rs10248420 and rs2032583 associated with colonic disease