rs4148739

A SNP in the ABCB1 gene on chromosome 7. Its most notable genotype is C;T: possibly, inpatients more likely to remit on certain antidepressants

Gene
ABCB1
Location
Chr 787,531,733 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
13%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TNot ratedpossibly normal probability of remission for inpatients on certain antidepressantsTypical · 0.072% of people
  2. C;TMost notableGoodpossibly, inpatients more likely to remit on certain antidepressantsMinor · 1.025% of people
  3. C;CGoodpossibly, inpatients more likely to remit on certain antidepressantsMinor · 1.03% of people

SNPedia records rs4148739 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 72% C;T 25% C;C 3%
  • European ancestry (Utah)T;T 72% C;T 27% C;C <1%
  • Han Chinese (Beijing)T;T 91% C;T 10% C;C 0%
  • Japanese (Tokyo)T;T 82% C;T 16% C;C 2%
  • Yoruba (Nigeria)T;T 56% C;T 36% C;C 8%
  • African ancestry (Southwest US)T;T 65% C;T 32% C;C 4%
  • Chinese (Denver)T;T 94% C;T 6% C;C 0%
  • Gujarati IndianT;T 65% C;T 33% C;C 2%
  • Luhya (Kenya)T;T 61% C;T 32% C;C 7%
  • Mexican ancestry (Los Angeles)T;T 79% C;T 21% C;C 0%
  • Maasai (Kenya)T;T 62% C;T 32% C;C 6%
  • TuscanT;T 71% C;T 28% C;C 2%

Conditions, medicines and genes

Other ABCB1 SNPs

All ABCB1 SNPs

Notes

From SNPedia

Show notes, about 280 words

rs4148739 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and their efficacy or potential for adverse side effects. However, the link between the increased brain concentrations of antidepressants and a clinically significant response is unconfirmed. In clinic, even the lower concentrations of drugs may achieve sufficient antidepressant effect, and the dose of the drug can be adjusted upwards until the patient responds. According to a recent review , ten studies reported that ABCB1 SNPs have clinical effect in depression and eight that they do not. rs4148739 is one of 9 SNPs found within a tight linkage block (r 2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below. When treated for depression with citalopram, paroxetine, amitriptyline, or venlafaxine (substrates of the protein encoded by ABCB1), a highly statistically significant association between the overall genetic variability of these SNPs and the remission was reported by Uhr et al in a study of ~400 German inpatients. However, this result has to be treated with caution. A well-run, double-blind study of ABCB1 substrate citalopram in depression (STAR-D study) and a following meta-analysis failed to replicate several Uhr et al. results for other ABCB1 SNPs. The 9 SNPs in the linkage block identified are : * rs2235067 * rs4148740 * rs2032583 * rs4148739 * rs11983225 * rs2235040 * rs12720067 * rs7787082 * rs10248420

Source and license

Adapted from rs4148739 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.