rs748404

A SNP in the TGM5 gene on chromosome 15. Its most notable genotype is T;T: slightly increased risk (1.25) for lung cancer

Gene
TGM5
Location
Chr 1543,267,033 (GRCh38)
Highest magnitude
1.3Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
15%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratedNo summary available.Typical · 0.03% of people
  2. C;TBadvery slightly increased risk (1.15) for lung cancerMinor · 1.125% of people
  3. T;TMost notableBadslightly increased risk (1.25) for lung cancerMinor · 1.372% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 3% C;T 25% T;T 72%
  • European ancestry (Utah)C;C 4% C;T 39% T;T 58%
  • Han Chinese (Beijing)C;C <1% C;T 12% T;T 88%
  • Japanese (Tokyo)C;C 0% C;T 12% T;T 88%
  • Yoruba (Nigeria)C;C 1% C;T 5% T;T 93%
  • African ancestry (Southwest US)C;C 4% C;T 9% T;T 88%
  • Chinese (Denver)C;C 0% C;T 14% T;T 86%
  • Gujarati IndianC;C 9% C;T 46% T;T 46%
  • Luhya (Kenya)C;C <1% C;T 20% T;T 79%
  • Mexican ancestry (Los Angeles)C;C 10% C;T 38% T;T 52%
  • Maasai (Kenya)C;C 3% C;T 35% T;T 63%
  • TuscanC;C 4% C;T 42% T;T 54%

Conditions, medicines and genes

Notes

From SNPedia

Notes

In a GWAS dataset of 1,447 lung cancer cases, and then replicated in another 1300 cases, the rs748404(T) allele was significantly correlated with increased risk (odds ratio 1.15, p = 1.1 &#215; 10e-9), in agreement with a previous meta-analysis.

Source and license

Adapted from rs748404 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.