rs663048

A SNP in the SEZ6L gene on chromosome 22. Its most notable genotype is T;T: 3x increased risk of developing lung cancer

Gene
SEZ6L
Location
Chr 2226,299,111 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodNormal risk of developing lung cancerMinor · 1.067% of people
  2. G;TBadSignificantly increased risk of developing lung cancerWorth knowing · 2.028% of people
  3. T;TMost notableBad3x increased risk of developing lung cancerWorth knowing · 2.55% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 67% G;T 28% T;T 5%
  • European ancestry (Utah)G;G 67% G;T 28% T;T 4%
  • Han Chinese (Beijing)G;G 92% G;T 7% T;T <1%
  • Japanese (Tokyo)G;G 88% G;T 12% T;T 0%
  • Yoruba (Nigeria)G;G 40% G;T 43% T;T 18%
  • African ancestry (Southwest US)G;G 46% G;T 44% T;T 11%
  • Chinese (Denver)G;G 91% G;T 8% T;T <1%
  • Gujarati IndianG;G 84% G;T 14% T;T 2%
  • Luhya (Kenya)G;G 50% G;T 42% T;T 8%
  • Mexican ancestry (Los Angeles)G;G 76% G;T 22% T;T 2%
  • Maasai (Kenya)G;G 47% G;T 47% T;T 6%
  • TuscanG;G 53% G;T 43% T;T 4%

Conditions, medicines and genes

Other SEZ6L SNPs

All SEZ6L SNPs

Notes

From SNPedia

Notes

rs663048 associated with lung cancer The homozygotes for the variant allele had more than a 3-fold risk compared with the wild-type homozygotes [combined odds ratio (OR), 3.32; 95% confidence interval (95% CI), 1.81-7.21]. Heterozygotes also had a significantly elevated risk of lung cancer from the combined replication studies with an OR of 1.15 (95% CI, 1.04-1.59). The effect remained significant after adjusting for age, gender, and pack-years of tobacco smoke.007;67(17):8406-11].

Source and license

Adapted from rs663048 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.