rs688034

A SNP in the SEZ6L gene on chromosome 22. Its most notable genotype is T;T: 1.6x risk

Gene
SEZ6L
Location
Chr 2226,293,669 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratednormalTypical · 0.077% of people
  2. C;TBad1.1x risk higher risk for coronary artery diseaseMinor · 1.120% of people
  3. T;TMost notableBad1.6x riskWorth knowing · 2.03% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 77% C;T 20% T;T 3%
  • European ancestry (Utah)C;C 45% C;T 43% T;T 12%
  • Han Chinese (Beijing)C;C 99% C;T <1% T;T 0%
  • Japanese (Tokyo)C;C 100% C;T 0% T;T 0%
  • Yoruba (Nigeria)C;C 91% C;T 10% T;T 0%
  • African ancestry (Southwest US)C;C 75% C;T 21% T;T 4%
  • Gujarati IndianC;C 86% C;T 13% T;T 1%
  • Luhya (Kenya)C;C 86% C;T 14% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 66% C;T 31% T;T 3%
  • Maasai (Kenya)C;C 76% C;T 22% T;T 1%
  • TuscanC;C 46% C;T 44% T;T 10%

Conditions, medicines and genes

Other SEZ6L SNPs

All SEZ6L SNPs

Notes

From SNPedia

Notes

rs688034 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.11 (CI 0.98-1.25), and for homozygotes, 1.62 (CI 1.34-1.95).

T;T

1.6x higher risk for coronary artery disease

Source and license

Adapted from rs688034 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.