rs8178085

A SNP in the PRKDC gene on chromosome 8. Its most notable genotype is T;T: common in complete genomics

Gene
PRKDC
Location
Chr 847,898,144 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
3%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodcommon in complete genomicsTypical · 0.091% of people

SNPedia records rs8178085 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageT;T 91%
  • European ancestry (Utah)T;T 100%
  • Han Chinese (Beijing)T;T 85%
  • Japanese (Tokyo)T;T 91%
  • Yoruba (Nigeria)T;T 91%
  • African ancestry (Southwest US)T;T 93%
  • Chinese (Denver)T;T 84%
  • Gujarati IndianT;T 99%
  • Luhya (Kenya)T;T 86%
  • Maasai (Kenya)T;T 94%

Conditions, medicines and genes

Other PRKDC SNPs

All PRKDC SNPs

Notes

From SNPedia

Notes

rs8178085 and rs12334811 with approaching dose-dependent effect on lung cancer predisposition, subjects carrying two to four risk genotypes were associated with a 43% decreased lung cancer risk compared with subjects carrying zero to one risk genotypes (adjusted odds ratio, 0.53; 95% confidence interval, 0.35-0.80). rs228591 variant allele or ataxia-telangiectasia and Rad3-related rs6782400 wild-type homozygous genotype

Source and license

Adapted from rs8178085 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.