rs7003908

A SNP in the PRKDC gene on chromosome 8. Its most notable genotype is A;A: normal

Gene
PRKDC
Location
Chr 847,858,141 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
29%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.047% of people
  2. A;CNot ratednormalTypical · 0.042% of people
  3. C;CNot rated1.4x increased risk for glioblastomaTypical · 0.012% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 47% A;C 42% C;C 12%
  • European ancestry (Utah)A;A 42% A;C 46% C;C 13%
  • Han Chinese (Beijing)A;A 66% A;C 29% C;C 5%
  • Japanese (Tokyo)A;A 57% A;C 35% C;C 8%
  • Yoruba (Nigeria)A;A 50% A;C 41% C;C 10%
  • African ancestry (Southwest US)A;A 40% A;C 46% C;C 14%
  • Chinese (Denver)A;A 54% A;C 39% C;C 6%
  • Gujarati IndianA;A 25% A;C 55% C;C 21%
  • Luhya (Kenya)A;A 51% A;C 42% C;C 7%
  • Mexican ancestry (Los Angeles)A;A 57% A;C 31% C;C 12%
  • Maasai (Kenya)A;A 44% A;C 43% C;C 12%
  • TuscanA;A 30% A;C 51% C;C 19%

Other PRKDC SNPs

All PRKDC SNPs

Notes

From SNPedia

Notes

A study of 1,000 glioblastoma multiforme cases and 2,000 controls in the US concluded that the PRKDC gene rs7003908(C;C) genotype was associated with an increase in risk for glioblastoma multiforme (odds ratio 1.44, CI: 1.13-1.84).

Source and license

Adapted from rs7003908 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.