rs11614913

A SNP in the MIR196A2 gene on chromosome 12. Its most notable genotype is C;C: Somewhat increased risk of various types of cancer

Gene
MIR196A2
Location
Chr 1253,991,815 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadSomewhat increased risk of various types of cancerWorth knowing · 2.043% of people
  2. C;TNot ratednormalTypical · 0.041% of people
  3. T;TGooddecreased risk for colorectal cancer and lung cancerWorth knowing · 2.016% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 43% C;T 41% T;T 16%
  • European ancestry (Utah)C;C 34% C;T 44% T;T 22%
  • Han Chinese (Beijing)C;C 20% C;T 49% T;T 31%
  • Japanese (Tokyo)C;C 16% C;T 47% T;T 37%
  • Yoruba (Nigeria)C;C 74% C;T 25% T;T 1%
  • African ancestry (Southwest US)C;C 60% C;T 35% T;T 5%
  • Chinese (Denver)C;C 17% C;T 45% T;T 39%
  • Gujarati IndianC;C 49% C;T 47% T;T 5%
  • Luhya (Kenya)C;C 76% C;T 23% T;T <1%
  • Mexican ancestry (Los Angeles)C;C 37% C;T 46% T;T 18%
  • Maasai (Kenya)C;C 50% C;T 45% T;T 5%
  • TuscanC;C 40% C;T 49% T;T 11%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 410 words

miRNA sequences and non-small cell lung cancer rs11614913 SNP in hsa-mir-196a2 was associated with survival in individuals with NSCLC. Specifically, survival was significantly decreased in individuals who were homozygous CC at SNP rs11614913. microRNA 1,009 breast cancer cases and 1,093 controls in a population of Chinese women *rs11614913 in hsa-mir-196a2 T>C 1.23; 95% confidence interval [CI], 1.02-1.48 *rs3746444 in hsa-mir-499 A>G OR 1.25; 95% CI, 1.02-1.51 Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. Signatures of purifying and local positive selection in human miRNAs. Update in lung cancer 2008. Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes. SNPs in human miRNA genes affect biogenesis and function. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. MicroRNA polymorphisms: a giant leap towards personalized medicine. Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population. Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma. Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India. A genetic variant in microRNA-196a2 is associated with increased cancer risk: a meta-analysis. Association between single-nucleotide polymorphisms in pre-miRNAs and the risk of asthma in a Chinese population. A functional polymorphism in pre-microRNA-196a-2 contributes to the susceptibility of hepatocellular carcinoma in a Turkish population: a case-control study. Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers. Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population. Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease. Lack of association of polymorphism in miRNA-196a2 with Parkinson's disease risk in a Chinese population. Impact of MiRSNPs on Survival and Progression in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation.

C;C

This variant increases risk (somewhat) for numerous types of cancer in many studies. It is in a microRNA

T;T

source

References

Source and license

Adapted from rs11614913 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.