rs12050604

A SNP in the UBR1 gene on chromosome 15. Its most notable genotype is A;A: slightly increased risk for lung cancer

Gene
UBR1
Location
Chr 1543,065,208 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadslightly increased risk for lung cancerMinor · 1.240% of people
  2. A;CBadvery slightly increased risk for lung cancerMinor · 1.134% of people
  3. C;CNot ratedNo summary available.Typical · 0.026% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 40% A;C 34% C;C 26%
  • European ancestry (Utah)A;A 12% A;C 36% C;C 52%
  • Han Chinese (Beijing)A;A 21% A;C 50% C;C 29%
  • Japanese (Tokyo)A;A 16% A;C 49% C;C 35%
  • Yoruba (Nigeria)A;A 99% A;C <1% C;C 0%
  • African ancestry (Southwest US)A;A 75% A;C 25% C;C 0%
  • Chinese (Denver)A;A 16% A;C 43% C;C 41%
  • Gujarati IndianA;A 17% A;C 56% C;C 27%
  • Luhya (Kenya)A;A 94% A;C 6% C;C 0%
  • Mexican ancestry (Los Angeles)A;A 16% A;C 35% C;C 50%
  • Maasai (Kenya)A;A 65% A;C 32% C;C 3%
  • TuscanA;A 12% A;C 38% C;C 50%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A GWAS study found a (slight but significant) association between rs12050604 and risk for lung cancer, with an odds ratio of 1.09 (p = 3.6 &#215; 10e-6).

Source and license

Adapted from rs12050604 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.