rs2066853

A SNP in the AHR gene on chromosome 7. Its most notable genotype is G;G.

Gene
AHR
Location
Chr 717,339,486 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
27%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedNo summary available.Typical · 0.051% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 51%
  • European ancestry (Utah)G;G 81%
  • Han Chinese (Beijing)G;G 38%
  • Japanese (Tokyo)G;G 29%
  • Yoruba (Nigeria)G;G 30%
  • African ancestry (Southwest US)G;G 32%
  • Chinese (Denver)G;G 42%
  • Gujarati IndianG;G 81%
  • Luhya (Kenya)G;G 26%
  • Mexican ancestry (Los Angeles)G;G 74%
  • Maasai (Kenya)G;G 43%
  • TuscanG;G 82%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2066853 has been associated with increased risk for colorectal polyps depending on the amount of meat eaten or overall exposure to heterocyclic amines. lung cancer in a Chinese population heterozygous rs2158041 OR=1.53 for GA vs compared with the (G;G) and rs7811989 OR=1.48 for (G;A) compared with the GG genotype) *rs2066853 (p.Arg554Lys) and cumulative cigarette smoking and the Lys/Lys genotype conferred an increased risk of lung cancer in the heavy smokers OR=3.36

Source and license

Adapted from rs2066853 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.