rs45446698

A SNP in the ZSCAN25 gene on chromosome 7. Its most notable genotype is G;G: Carrier of two CYP3A7*1C alleles; possibly reduced contraceptive effectiveness and moderately increased cancer risk

Gene
ZSCAN25
Location
Chr 799,735,325 (GRCh38)
Highest magnitude
3.9Important
Tested on
23andMe

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon/normalTypical · 0.0
  2. G;TBadCarrier of a CYP3A7*1C allele; possibly reduced contraceptive effectiveness and slightly increased cancer riskImportant · 3.0
  3. G;GMost notableBadCarrier of two CYP3A7*1C alleles; possibly reduced contraceptive effectiveness and moderately increased cancer riskImportant · 3.9

SNPedia records rs45446698 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 120 words

http://www.healio.com/hematology-oncology/breast-cancer/news/online/%7B5c3d7a03-189f-4da6-8f37-e2a6a6c91c7b%7D/cyp3a7-allele-predicts-poor-outcomes-for-lung-and-breast-cancer-leukemia CYP3A7 is normally turned on in an embryo, then turned off at birth. However, individuals with one of more copy of the gene (CYP3A7*1C) turn on their CYP3A7 gene in adult life. C allele increased risk of breast cancer, lung cancer, and CLL. Analyses adjusted for prognostic factors showed harboring the SNP increased risk for disease-specific mortality 74% among patients with breast cancer (HR = 1.74; 95% CI, 1.05-2.9) and 43% among patients with lung cancer (HR = 1.43; 95% CI, 1.09-1.87).

G;T

see text and links via main rs-page

G;G

see text and links via main rs-page

Source and license

Adapted from rs45446698 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.