rs1169300
A SNP in the HNF1A gene on chromosome 12. Its most notable genotype is A;A: ~2x increased lung cancer risk
- Gene
- HNF1A
- Location
- Chr 12120,993,422 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 33%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBad~2x increased lung cancer risk
- A;GBad~1.5x increased lung cancer risk
- G;GNot ratednormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 12% A;G 40% G;G 48%
- European ancestry (Utah)A;A 7% A;G 45% G;G 48%
- Han Chinese (Beijing)A;A 20% A;G 55% G;G 26%
- Japanese (Tokyo)A;A 35% A;G 54% G;G 12%
- Yoruba (Nigeria)A;A 1% A;G 13% G;G 86%
- African ancestry (Southwest US)A;A 0% A;G 28% G;G 72%
- Chinese (Denver)A;A 22% A;G 48% G;G 31%
- Gujarati IndianA;A 20% A;G 45% G;G 36%
- Luhya (Kenya)A;A 3% A;G 29% G;G 68%
- Mexican ancestry (Los Angeles)A;A 14% A;G 39% G;G 47%
- Maasai (Kenya)A;A 2% A;G 43% G;G 56%
- TuscanA;A 11% A;G 44% G;G 45%
Related
Conditions, medicines and genes
Other HNF1A SNPs
- rs137853236C;TMaturity onset of diabetes of the young (type 3)Important
- rs137853237A;GMaturity onset of diabetes of the young (type 3)Important
- rs137853239C;GMature onset diabetes of the young (type 3)Important
- rs137853243C;TMaturity onset of diabetes of the young (type 3)Important
- rs137853244C;TMaturity onset of diabetes of the young (type 3)Important
- rs137853245A;CMaturity onset of diabetes of the young (type 3)Important
- rs137853246C;GMaturity onset of diabetes of the young (type 3)Important
- rs150513055C;TMature onset diabetes of the young (type 3)Important
Notes
From SNPedia
Show notes, about 130 words
rs1169300 is a SNP that was originally associated with C-reactive protein levels, and given other findings that suggest C-reactive protein levels may be predictive of cancer risk, was thought to be linked to cancer risk. A large study pooling data from 3 Finnish studies totaling over 18,000 individuals concluded that while this SNP is not likely to be causative (relative to cancer), it and one other CRP SNP (rs2464196) are associated with increased risk for lung cancer. The odds ratio for minor alleles of either SNP was about 1.5x and 2x for heterozygotes and homozygotes, respectively. One other CRP SNP (rs1892534) was associated with increased overall cancer risk. CRP SNPs were not associated with colorectal, prostate or breast cancer risk.
Source and license
Adapted from rs1169300 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.