Ovarian cancer

45 SNPs linked to Ovarian cancer across 27 genes, 19 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 45
Notable: 19Magnitude 2 or higher
Well documented: 36
Genes: 27

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs28897672BRCA1Very important
- A;Tconsidered a pathogenic BRCA1 breast cancer variantBad
- A;Gconsidered a pathogenic BRCA1 breast cancer variantBad
- C;Cconsidered a pathogenic BRCA1 breast cancer variantBad
- A;Cconsidered a pathogenic BRCA1 breast cancer variantBad
- A;AnormalGood
rs41293455BRCA1Very important
- G;GnormalGood
- C;GBRCA1 variant that is probably benignNot rated
- A;GBRCA1 variant considered pathogenic for breast cancerBad
- A;Apredisposition to breast cancer?Not rated
rs80357438BRCA1Very important
- A;TBRCA1 variant considered likely to be pathogenic for ovarian cancer (by ClinVar)Bad
- A;GBRCA1 variant considered pathogenic for breast cancer (by most ClinVar submitters)Bad
- A;Acommon in clinvarGood
rs80359604BRCA2Very important
- -;GTBRCA2 variant considered pathogenic for breast cancerBad
- GT;GTcommon/normalGood
rs587778134BRIP1Very important
- -;-common/normalGood
- -;TTOvarian cancer susceptibilityBad
rs1042838PGRImportant
- C;Cnormal riskGood
- A;C1.28x risk for endometrial ovarian cancer; overlaps with rs608995Bad
- A;A1.42x risk for endometrial ovarian cancer; overlaps with rs608995Bad
rs2910164MIR146AWorth knowing
- C;Chigher cancer risk ? (ambiguous flip)Bad
- C;Ghigher/earlier cancer likelihood??Not rated
- G;GnormalGood
rs7651446TIPARPWorth knowing
- G;Gcommon/normalGood
- G;T1.5x increased risk for epithelial ovarian cancerBad
- T;T2.25x increased risk for epithelial ovarian cancerBad
rs1219648FGFR2Worth knowing
- A;ANo summary available.Good
- A;G1.20x risk for breast cancerBad
- G;G1.64x risk for breast cancerBad
rs2273535AURKAWorth knowing
- A;AcommonNot rated
- A;Tslightly higher (~1.5x or less) risk for certain cancersBad
- T;Tslightly higher (~1.5x or less) risk for certain cancersBad
rs662PON1Worth knowing
- T;T~2x higher risk of of coronary heart disease reported in some studies, but lower risk seen in other studiesBad
- C;T0.65x lower risk of ovarian cancer; higher risk of coronary heart disease in some studies; somewhat reduced PON catalytic efficiencyNot rated
- C;CMixed; conflicting results reported related to stroke and CADNot rated
rs13181ERCC2Worth knowing
- G;G>1.12x increased risk for cutaneous melanoma; possible increase in ovarian cancer riskBad
- G;T1.12x increased risk for cutaneous melanomaBad
- T;TNormal risk for cutaneous melanomaGood
rs1045485CASP8Worth knowing
- C;CReduced Risk of Breast CancerGood
- C;Gslightly (0.89x) lowered risk for breast cancerGood
- G;Gcommon/normalGood
rs1800709BRCA1Worth knowing
- G;GnormalGood
- A;Gpossible predisposition to breast cancerNot rated
- C;CNo summary available.Not rated
- A;Apredisposition to breast cancer?Not rated
rs2740574CYP3AWorth knowing
- T;TnormalGood
- C;Tcarrier of one CYP3A4*1B alleleNot rated
- C;C2.5x increased risk for prostate or ovarian cancer; CYP3A4*1B homozygoteNot rated
rs3218536XRCC2Worth knowing
- T;Tlower risk for breast, ovarian cancerGood
- C;Tlower risk for breast, ovarian cancerGood
- C;Cnormal riskNot rated
rs4986852BRCA1Worth knowing
- T;Tpredisposition to breast cancer?Not rated
- C;Tpossible predisposition to breast cancerNot rated
- G;GNo summary available.Not rated
- C;CnormalGood
rs10088218LINC00824Worth knowing
- A;A0.5x decreased risk for ovarian cancerGood
- A;G0.76x decreased risk for ovarian cancerGood
- G;GNo summary available.Not rated
rs41293459BRCA1Worth knowing
- G;Gcommon/normalGood
- A;Gincreased risk for breast cancerBad
- C;Ccommon in clinvarGood
rs3814113Minor
- C;C0.8x decreased risk for ovarian cancerGood
- C;T0.8x decreased risk for ovarian cancerGood
- T;TnormalNot rated
rs176026MAGEC3Minor
- A;Amost common allele in Caucasians and Hispanics (but not Africans or some Asian populations)Good
- A;GSlightly higher (~1.4x?) risk for ovarian cancerBad
- G;GSlightly higher (~1.4x?) risk for ovarian cancerBad
rs2072590HAGLRMinor
- C;CNo summary available.Not rated
- A;C1.2x increased risk for ovarian cancerBad
- A;A1.4x increased risk for ovarian cancerNot rated
rs2665390TIPARPMinor
- C;C1.4x increased risk for ovarian cancerBad
- C;T1.2x increased risk for ovarian cancerBad
- T;Tcommon in complete genomicsGood
rs4320932INS-IGF2Minor
- T;TnormalNot rated
- C;T0.87x decreased risk for ovarian cancerGood
- C;C0.74x decreased risk for ovarian cancerGood
rs2295190ESR1Minor
- G;GcommonGood
- G;TSlightly increased risk for ovarian cancer in womenBad
- T;TSlightly increased risk for ovarian cancer in womenBad
rs9303542SKAP1Minor
- A;ANo summary available.Not rated
- A;G1.1x increased risk for ovarian cancerNot rated
- G;G1.2x increased risk for ovarian cancerNot rated
rs523349SRD5A2Typical
- C;CNo summary available.Not rated
- C;Gincreased ovarian cancer riskBad
- G;Gcommon in clinvarGood
rs1271572ESR2Typical
- C;CnormalNot rated
- A;C1.65x increased risk only in men for myocardial infarctionNot rated
- A;A1.65x increased risk only in men for myocardial infarction; 1.8x increased risk in females for ovarian cancerNot rated
rs1982073TGFB1Typical
- G;Grisk genotype for several disordersNot rated
- A;Grisk genotype for several disordersNot rated
- A;Arisk genotype for several disordersNot rated
rs2227311RB1Typical
- A;ANo summary available.Good
rs2287498TP53Typical
- C;Ccommon in clinvarGood
rs2854344RB1Typical
- A;ANo summary available.Not rated
- A;GNo summary available.Not rated
- G;GNo summary available.Good
rs3731239CDKN2ATypical
- G;G0.9x lower risk for breast cancerGood
- A;G?Good
- A;Anormal riskNot rated
rs4151620RB1Typical
- C;GNo summary available.Not rated
rs11782652CHMP4CTypical
- A;ANo summary available.Good
rs17647532GALNT1Typical
- C;Creduced risk for ovarian cancer originally reported, but did not replicate in larger studyNot rated
- C;Tnormal risk?Not rated
- T;Tnormal riskNot rated

Genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 9 SNPs

Source and license

Adapted from Ovarian cancer on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.