rs2740574

A SNP in the CYP3A gene on chromosome 7. Its most notable genotype is C;C: 2.5x increased risk for prostate or ovarian cancer; CYP3A4*1B homozygote

Gene
CYP3A
Location
Chr 799,784,473 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
20%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodnormalTypical · 0.0
  2. C;TNot ratedcarrier of one CYP3A4*1B alleleTypical · 0.0
  3. C;CMost notableNot rated2.5x increased risk for prostate or ovarian cancer; CYP3A4*1B homozygoteWorth knowing · 2.0

SNPedia records rs2740574 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

The rs2740574(G) allele encodes a variant form of CYP3A4 known as CYP3A4*1B. rs2740574(G) alleles are associated with an ~10 fold higher risk of aggressive prostate cancer in African American males. PMID 16414488, OMIM ncbi.nlm.nih.gov] A pooled study (1,400+ samples) along with a replication study conducted by members of the Ovarian Cancer Association Consortium found a 2.5-2.8x increased risk for ovarian cancer for rs2740574(G;G) individuals (CI: 1.2-6.5, p=0.017). The authors note that CYP3A4 encodes a key enzyme in estrogen metabolism and which may be linked to ovarian carcinogenesis.

Source and license

Adapted from rs2740574 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.