rs9303542

A SNP in the SKAP1 gene on chromosome 17. Its most notable genotype is G;G: 1.2x increased risk for ovarian cancer

Gene
SKAP1
Location
Chr 1748,334,138 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNo summary available.Typical · 0.054% of people
  2. A;GNot rated1.1x increased risk for ovarian cancerMinor · 1.137% of people
  3. G;GMost notableNot rated1.2x increased risk for ovarian cancerMinor · 1.28% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 54% A;G 37% G;G 8%
  • European ancestry (Utah)A;A 48% A;G 47% G;G 5%
  • Han Chinese (Beijing)A;A 74% A;G 24% G;G 2%
  • Japanese (Tokyo)A;A 71% A;G 24% G;G 5%
  • Yoruba (Nigeria)A;A 25% A;G 54% G;G 21%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs9303542 is a SNP on chromosome 17q21, located in the intron of src kinase associated phosphoprotein 1 SKAP1 gene. A genome-wide association study ultimately including over 10,000 ovarian cancer patients found statistically strong (p = 1.4 × 10e-7) evidence for slightly elevated risk associated with the rs9303542(G) allele, with an odds ratio of 1.14 (CI: 1.09–1.20) as calculated for the serous subtype (of ovarian cancer).

Source and license

Adapted from rs9303542 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.