rs17647532

A SNP in the GALNT1 gene on chromosome 18. Its most notable genotype is C;C: reduced risk for ovarian cancer originally reported, but did not replicate in larger study

Gene
GALNT1
Location
Chr 1835,654,108 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
10%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedreduced risk for ovarian cancer originally reported, but did not replicate in larger studyTypical · 0.02% of people
  2. C;TNot ratednormal risk?Typical · 0.012% of people
  3. T;TNot ratednormal riskTypical · 0.086% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 2% C;T 12% T;T 86%
  • European ancestry (Utah)C;C 0% C;T 17% T;T 83%
  • Han Chinese (Beijing)C;C 0% C;T 11% T;T 89%
  • Japanese (Tokyo)C;C 0% C;T 4% T;T 96%
  • Yoruba (Nigeria)C;C 7% C;T 16% T;T 77%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 120 words

rs17647532 is a SNP in the GALNT1 gene that has a variant rarely seen in ovarian cancer, which may indicate it is a protective genotype. In a study of 829 patients, the rs17647532(C;C) homozygous genotype was calculated to have an odds ratio for developing ovarian cancer of 0.07 (CI: 0.01-0.53, p=0.00017). Unfortunately, perhaps, a subsequent (larger) study by the same authors using 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium was not able to find any significant association between this SNP and risk for (or from) ovarian cancer. As the authors state, "this study underscores the need for replication of putative findings in genetic association studies".

Source and license

Adapted from rs17647532 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.