rs7651446

A SNP in the TIPARP gene on chromosome 3. Its most notable genotype is T;T: 2.25x increased risk for epithelial ovarian cancer

Gene
TIPARP
Location
Chr 3156,689,208 (GRCh38)
Highest magnitude
2.2Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
6%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodcommon/normalTypical · 0.085% of people
  2. G;TBad1.5x increased risk for epithelial ovarian cancerWorth knowing · 2.014% of people
  3. T;TMost notableBad2.25x increased risk for epithelial ovarian cancerWorth knowing · 2.21% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageG;G 85% G;T 14% T;T 1%
  • European ancestry (Utah)G;G 90% G;T 10% T;T 0%
  • Han Chinese (Beijing)G;G 99% G;T <1% T;T 0%
  • Japanese (Tokyo)G;G 100% G;T 0% T;T 0%
  • Yoruba (Nigeria)G;G 64% G;T 32% T;T 4%
  • African ancestry (Southwest US)G;G 60% G;T 35% T;T 5%
  • Luhya (Kenya)G;G 82% G;T 18% T;T 0%
  • Mexican ancestry (Los Angeles)G;G 91% G;T 9% T;T 0%
  • Maasai (Kenya)G;G 81% G;T 19% T;T <1%
  • TuscanG;G 95% G;T 5% T;T 0%

Conditions, medicines and genes

Other TIPARP SNPs

All TIPARP SNPs

Notes

From SNPedia

Show notes, about 130 words

rs7651446 is a SNP within the TCDD-inducible poly(ADP-ribose) polymerase TIPARP gene on chromosome 3. Although not the first report, the first large validation associating the rs7651446(T) allele with increased risk for epithelial ovarian cancer came from a study of 18,174 individuals from 43 studies from the Ovarian Cancer Association Consortium. Subsequently, another study of over 18,000 patients, including BRCA1 and BRCA2 carriers as well as a meta-analysis, validated this association as the strongest (in terms of increasing risk) of a total of 18 known risk loci. The rs7651466(T) allele was reported as having a hazard ratio of between 1.50 - 1.94, depending on genetic background, with p values 10e-8 or lower.

G;T

See discussion at rs7651446.

T;T

See discussion at rs7651446.

Source and license

Adapted from rs7651446 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.