rs2665390

A SNP in the TIPARP gene on chromosome 3. Its most notable genotype is C;C: 1.4x increased risk for ovarian cancer

Gene
TIPARP
Location
Chr 3156,679,960 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
6%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.4x increased risk for ovarian cancerMinor · 1.4<1% of people
  2. C;TBad1.2x increased risk for ovarian cancerMinor · 1.210% of people
  3. T;TGoodcommon in complete genomicsTypical · 0.089% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C <1% C;T 10% T;T 89%
  • European ancestry (Utah)C;C 0% C;T 13% T;T 87%
  • Han Chinese (Beijing)C;C <1% C;T 6% T;T 93%
  • Japanese (Tokyo)C;C 0% C;T 5% T;T 96%
  • Yoruba (Nigeria)C;C <1% C;T 18% T;T 81%
  • African ancestry (Southwest US)C;C 0% C;T 12% T;T 88%
  • Chinese (Denver)C;C 0% C;T 7% T;T 93%
  • Gujarati IndianC;C 1% C;T 12% T;T 87%
  • Luhya (Kenya)C;C 0% C;T 9% T;T 91%
  • Mexican ancestry (Los Angeles)C;C 0% C;T 7% T;T 93%
  • Maasai (Kenya)C;C 0% C;T 14% T;T 86%
  • TuscanC;C 0% C;T 11% T;T 89%

Conditions, medicines and genes

Other TIPARP SNPs

All TIPARP SNPs

Notes

From SNPedia

Notes

rs2665390 is a SNP in chromosomal region 3q25, in the TCDD-inducible poly(ADP-ribose) polymerase TIPARP gene. A genome-wide association study ultimately including over 10,000 ovarian cancer patients found statistically strong (p = 7.1 &#215; 10e-8) evidence for slightly elevated risk associated with the rs2665390(C) allele, with an odds ratio of 1.24 (CI: 1.15&#8211;1.34) as calculated for the serous subtype (of ovarian cancer).

Source and license

Adapted from rs2665390 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.