rs4151620
A SNP in the RB1 gene on chromosome 13. Its most notable genotype is C;G.
- Gene
- RB1
- Location
- Chr 1348,474,923 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 10%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other RB1 SNPs
- rs3092891C;TRetinoblastoma (predicted)Very important
- rs121913296G;TRetinoblastoma (predicted)Very important
- rs121913300C;TRetinoblastoma (predicted)Very important
- rs121913301C;TRetinoblastoma (predicted)Very important
- rs121913302C;TRetinoblastoma (predicted)Very important
- rs121913303C;TRetinoblastoma (predicted)Very important
- rs121913304C;TRetinoblastoma (predicted)Very important
- rs121913305C;TRetinoblastoma (predicted)Very important
Notes
From SNPedia
Notes
rs4151620(C;G) and rs4151620(G;G) are associated with a reduced risk of ovarian cancer compared with rs4151620(G;G) individuals. This snp has been linked to ovarian cancer Intron 17 of RB1 contains the open reading frame for the P2RY5 gene, and rs4151620 is perfectly correlated with rs2227311, which is located in the 5'-untranslated region of P2RY5 and is predicted to affect P2RY5 transcription. rs2854344 has been reported previously to be associated with breast cancer risk
C;G
associated with reduced risk of ovarian cancer
Source and license
Adapted from rs4151620 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.