rs2287498
A SNP in the TP53 gene on chromosome 17. Its most notable genotype is C;C: common in clinvar
- Gene
- TP53
- Location
- Chr 177,689,242 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 18%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2287498 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 59%
- European ancestry (Utah)C;C 82%
- Han Chinese (Beijing)C;C 47%
- Japanese (Tokyo)C;C 60%
- Yoruba (Nigeria)C;C 48%
Related
Conditions, medicines and genes
Other TP53 SNPs
- rs28934578T;Tinfo@snpedia.com would like to hear from youVery important
- rs11540652C;TLi-Fraumeni Syndrome (predicted)Very important
- rs11575997C;TLi-Fraumeni Syndrome (predicted)Very important
- rs28934573C;GLi-Fraumeni Syndrome (predicted)Very important
- rs28934574C;GLi-Fraumeni Syndrome (predicted)Very important
- rs28934575C;TLi-Fraumeni Syndrome (predicted)Very important
- rs28934576C;TLi-Fraumeni Syndrome (predicted)Very important
- rs28934577A;CLi-Fraumeni Syndrome (predicted)Very important
Notes
From SNPedia
Notes
A study population including a total of 5,206 invasive ovarian cancer cases (2,829 of which were serous) and 8,790 controls found an association between rs2287498 and serous invasive cancer (median per allele odds ratio 1.30, CI: 1.07-1.57).
Source and license
Adapted from rs2287498 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.