rs10088218

A SNP in the LINC00824 gene on chromosome 8. Its most notable genotype is A;A: 0.5x decreased risk for ovarian cancer

Gene
LINC00824
Location
Chr 8128,531,703 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
8%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGood0.5x decreased risk for ovarian cancerWorth knowing · 2.01% of people
  2. A;GGood0.76x decreased risk for ovarian cancerMinor · 1.314% of people
  3. G;GNot ratedNo summary available.Typical · 0.085% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 1% A;G 14% G;G 85%
  • European ancestry (Utah)A;A <1% A;G 23% G;G 76%
  • Han Chinese (Beijing)A;A 0% A;G 3% G;G 97%
  • Japanese (Tokyo)A;A 0% A;G <1% G;G 99%
  • Yoruba (Nigeria)A;A 1% A;G 22% G;G 76%
  • African ancestry (Southwest US)A;A 4% A;G 21% G;G 75%
  • Chinese (Denver)A;A 0% A;G 3% G;G 97%
  • Gujarati IndianA;A 0% A;G 11% G;G 89%
  • Luhya (Kenya)A;A <1% A;G 23% G;G 76%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 12% G;G 88%
  • Maasai (Kenya)A;A 3% A;G 15% G;G 82%
  • TuscanA;A 2% A;G 16% G;G 82%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs10088218 is a SNP on chromosome 8q24, >700 kb distal to the CMYC gene in an area termed a 'gene desert'. A genome-wide association study ultimately including over 10,000 ovarian cancer patients found statistically strong (p = 8 &#215; 10e-15) evidence for slightly reduced risk associated with the rs10088218(A) allele, with an odds ratio of 0.76 (CI: 0.7 &#8211; 0.81) as calculated for the serous subtype (of ovarian cancer). A large study of over 18,000 patients with epithelial ovarian cancer, including BRCA1 and BRCA2 carriers and a meta-analysis, has also found similar levels of decreased risk for the rs10088218(A) allele.

Source and license

Adapted from rs10088218 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.