rs4320932

A SNP in the INS-IGF2 gene on chromosome 11. Its most notable genotype is C;C: 0.74x decreased risk for ovarian cancer

Gene
INS-IGF2
Location
Chr 112,150,371 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TNot ratednormalTypical · 0.054% of people
  2. C;TGood0.87x decreased risk for ovarian cancerMinor · 1.235% of people
  3. C;CMost notableGood0.74x decreased risk for ovarian cancerMinor · 1.411% of people

SNPedia records rs4320932 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 54% C;T 35% C;C 11%
  • European ancestry (Utah)T;T 61% C;T 37% C;C 2%
  • Han Chinese (Beijing)T;T 22% C;T 54% C;C 24%
  • Japanese (Tokyo)T;T 30% C;T 46% C;C 24%
  • Yoruba (Nigeria)T;T 84% C;T 16% C;C <1%
  • African ancestry (Southwest US)T;T 72% C;T 28% C;C 0%
  • Chinese (Denver)T;T 18% C;T 47% C;C 35%
  • Gujarati IndianT;T 37% C;T 49% C;C 15%
  • Luhya (Kenya)T;T 75% C;T 24% C;C 2%
  • Mexican ancestry (Los Angeles)T;T 85% C;T 16% C;C 0%
  • Maasai (Kenya)T;T 55% C;T 35% C;C 10%
  • TuscanT;T 57% C;T 35% C;C 8%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 150 words

rs4320932 is a SNP in the IF2 insulin-like growth factor 2 gene. A study totaling ~5,000 non-Hispanic white patients with ovarian cancer found a 13% decreased risk of ovarian cancer per copy of the rs4320932(G) allele carried (CI: 0.81-0.93, P-trend=7.4 &#215; 10e-5). Associated with schizophrenia in a study of Croatians. Due to the limited number (~100 patients) and diversity of the studied population, more study is needed to confirm any link. The G allele was associated with an increased risk of schizophrenia with P < 0.001. Small size study with 212 cases linked the G allele earlier found protective against ovarian cancer increasing relapse by 3.05 (95% confidence interval CI: 1.47&#8211;6.37, P-trend 2*10e-4) and mortality 3.28 (95% CI: 1.64&#8211;6.57, P-trend 6*10e-5). Association of Tagging Single Nucleotide Polymorphisms on 8 Candidate Genes in Dopaminergic Pathway with Schizophrenia in Croatian Population

Source and license

Adapted from rs4320932 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.