rs2910164

A SNP in the MIR146A gene on chromosome 5. Its most notable genotype is C;C: higher cancer risk ? (ambiguous flip)

Gene
MIR146A
Location
Chr 5160,485,411 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadhigher cancer risk ? (ambiguous flip)Worth knowing · 2.520% of people
  2. C;GNot ratedhigher/earlier cancer likelihood??Typical · 0.045% of people
  3. G;GGoodnormalTypical · 0.035% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 20% C;G 45% G;G 35%
  • European ancestry (Utah)C;C 6% C;G 35% G;G 59%
  • Han Chinese (Beijing)C;C 37% C;G 40% G;G 23%
  • Japanese (Tokyo)C;C 33% C;G 58% G;G 9%
  • Yoruba (Nigeria)C;C 21% C;G 48% G;G 31%
  • African ancestry (Southwest US)C;C 16% C;G 44% G;G 40%
  • Chinese (Denver)C;C 39% C;G 45% G;G 17%
  • Gujarati IndianC;C 8% C;G 39% G;G 54%
  • Luhya (Kenya)C;C 23% C;G 48% G;G 29%
  • Mexican ancestry (Los Angeles)C;C 7% C;G 52% G;G 41%
  • Maasai (Kenya)C;C 23% C;G 50% G;G 27%
  • TuscanC;C 7% C;G 37% G;G 56%

Conditions, medicines and genes

Other MIR146A SNPs

All MIR146A SNPs

Notes

From SNPedia

Notes

(C;C) predisposes to papillary thyroid carcinoma. Among 42 patients with familial breast cancer and 82 patients with ovarian cancer, those with at least one rs2910164(C) SNP tended to have been diagnosed at an earlier age than those with only (G) alleles. For the breast cancer patients, the difference in median age was between 45 vs 56 (p = 0.029) and for ovarian cancer patients, 45 vs 50, (p = 0.014). (G;G) males were two-fold more susceptible to hepatocellular carcinoma (OR = 2.016, 95% CI = 1.056-3.848, P = 0.034) perhaps an ambiguous flip?

Source and license

Adapted from rs2910164 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.