rs2961920
A SNP in the MIR146A gene on chromosome 5. Its most notable genotype is A;A.
- Gene
- MIR146A
- Location
- Chr 5160,484,499 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 38%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedNo summary available.
- A;CNot ratedNo summary available.
- C;CNot ratedNo summary available.
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 35% A;C 44% C;C 21%
- European ancestry (Utah)A;A 59% A;C 35% C;C 6%
- Han Chinese (Beijing)A;A 23% A;C 41% C;C 37%
- Japanese (Tokyo)A;A 9% A;C 57% C;C 35%
- Yoruba (Nigeria)A;A 31% A;C 47% C;C 22%
- African ancestry (Southwest US)A;A 42% A;C 40% C;C 18%
- Chinese (Denver)A;A 17% A;C 44% C;C 39%
- Gujarati IndianA;A 54% A;C 39% C;C 8%
- Luhya (Kenya)A;A 29% A;C 47% C;C 24%
- Mexican ancestry (Los Angeles)A;A 41% A;C 52% C;C 7%
- Maasai (Kenya)A;A 26% A;C 48% C;C 26%
- TuscanA;A 56% A;C 37% C;C 7%
Related
Notes
From SNPedia
Show notes, about 130 words
This study compared 608 patients of European ancestry with papillary thyroid cancer, which is the most common form of thyroid cancer and is highly treatable, to 901 healthy controls. The authors found an association between the SNP rs2910164, which is equivalent to the 23andMe SNP rs2961920, and risk for thyroid cancer. People with the AC genotype at rs2961920 had about 1.5 times the odds of papillary thyroid cancer compared to those with the AA genotype and about three times the odds compared to the CC genotype. Though this is an atypical risk pattern, the researchers speculate in a separate paper that having one copy of each form of the SNP increases production of molecules that regulate the cell's response to DNA damage, a process that is often involved in cancer.
Source and license
Adapted from rs2961920 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.