rs587778134
A SNP in the BRIP1 gene on chromosome 17. Its most notable genotype is -;TT: Ovarian cancer susceptibility
- Gene
- BRIP1
- Location
- Chr 1761,776,458 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (-;-), (-;TT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other BRIP1 SNPs
- rs137852986A;GIncreased cancer risk; ovarian cancer & relatedVery important
- rs149364097C;GOvarian cancer susceptibilityVery important
- rs368796923A;GIncreased cancer risk; ovarian cancer & relatedVery important
- rs574552037C;GIncreased cancer risk; ovarian cancer & relatedVery important
- rs575595017A;GIncreased cancer risk; ovarian cancer & relatedVery important
- rs587780226A;GOvarian cancer susceptibilityVery important
- rs587780228A;CIncreased cancer risk; ovarian cancer & relatedVery important
- rs587780236-;AIncreased cancer risk; ovarian cancer & relatedVery important
Notes
From SNPedia
Notes
rs587778134, also known as c.2040_2041insTT, c.2038_2039dupTT and p.Leu680Phefs, represents a rare mutation in the BRIP1 gene on chromosome 17. Following SNP discovery through full genome sequencing of 457 Icelanders, analysis of 656 patients with ovarian cancer led to the discovery of the association of the rare rs587778134(TT) allele with increased risk (for ovarian cancer). The odds ratio was reported as 8.13 (p = 2.8 × 10e−14). The mutation was also associated with increased risk of cancer in general and an overall reduced average lifespan of 3.6 years.
Source and license
Adapted from rs587778134 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.