rs80359604
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is -;GT: BRCA2 variant considered pathogenic for breast cancer
- Gene
- BRCA2
- Location
- Chr 1332,329,469 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (-;GT), (GT;GT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
Notes
From SNPedia
Show notes, about 130 words
rs80359604, also known as 886delGT, c.658_659delGT and p.Val220Ilefs, is a variant in the BRCA2 gene considered pathogenic for breast cancer in ClinVar.rs80359604, also known as 886delGT and Val220Ilefs, is a mutation in the BRCA2 gene on chromosome 13. A good starting place for information about this SNP is OMIM. Although there is some conflicting evidence, the deletion form of this SNP has been reported to be associated with several different (generally recessively inherited) conditions, including: * Breast-ovarian cancer, familial 2 * Fanconi anemia, complementation group D1 * Medulloblastoma * Wilms tumor 1 * Glioma susceptibility 3 * Pre-B-cell acute lymphoblastic leukemia * BRCA1 and BRCA2 Hereditary Breast cancer and Ovarian cancer 23andMe name: i5009241
-;GT
See details at rs80359604.
Source and license
Adapted from rs80359604 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.