rs28897743
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is A;G: considered a causal BRCA2 breast cancer mutation
- Gene
- BRCA2
- Location
- Chr 1332,346,896 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadconsidered a causal BRCA2 breast cancer mutation
- C;GBadBRCA2 variant considered pathogenic for breast cancer
- G;GGoodcommon in clinvar
- G;TBadBRCA2 variant considered pathogenic for breast cancer
On SNPedia: (A;G), (C;G), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 8 HapMap populations.
- AverageA;G 2% C;G 0% G;G 98% G;T 0%
- European ancestry (Utah)A;G <1% C;G 0% G;G 99% G;T 0%
- Han Chinese (Beijing)A;G 2% C;G 0% G;G 98% G;T 0%
- Japanese (Tokyo)A;G 3% C;G 0% G;G 97% G;T 0%
- Yoruba (Nigeria)A;G 1% C;G 0% G;G 99% G;T 0%
- African ancestry (Southwest US)A;G 2% C;G 0% G;G 98% G;T 0%
- Chinese (Denver)A;G <1% C;G 0% G;G 99% G;T 0%
- Luhya (Kenya)A;G 2% C;G 0% G;G 98% G;T 0%
- Mexican ancestry (Los Angeles)A;G 5% C;G 0% G;G 95% G;T 0%
Related
Conditions, medicines and genes
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293497A;Cconsidered a causal BRCA2 breast cancer mutationVery important
Notes
From SNPedia
Notes
rs28897743, also known as 7235G>T, c.7007G>T and p.Gly2313AlafsX31, as well as Arg2336His or R2336H, is a variant in the BRCA2 gene considered pathogenic for breast cancer in ClinVar and UMD. This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about. 23andMe has another SNP for this position, named i5009343.
A;G
see citations at rs28897743
G;T
See details at rs28897743
Source and license
Adapted from rs28897743 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.