rs28897756
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is A;A: BRCA2, breast cancer mutation
- Gene
- BRCA2
- Location
- Chr 1332,379,913 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadBRCA2, breast cancer mutation
- A;GBadconsidered a causal BRCA2 mutation for breast cancer
- G;GGoodnormal
- G;TBadBRCA2 variant considered pathogenic for breast cancer
On SNPedia: (A;A), (A;G), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293497A;Cconsidered a causal BRCA2 breast cancer mutationVery important
Notes
From SNPedia
Notes
rs28897756, also known as 9345G>A, c.9117G>A, p.Pro3039= and P3039P is a SNP in the breast cancer 2 BRCA2 gene. The rare rs28897756(A) allele has been linked to increased risk for breast cancer in some Dutch families.. It is considered a causal mutation for breast cancer by UMD and is denoted pathogenic in ClinVar. This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about. Another name used by 23andMe for this SNP is i5010626.
A;G
see citations at rs28897756
Source and license
Adapted from rs28897756 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.