rs28897746
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is C;T: BRCA2 variant considered pathogenic for breast cancer
- Gene
- BRCA2
- Location
- Chr 1332,363,259 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 6 HapMap populations.
- AverageC;T <1% T;T 99%
- Han Chinese (Beijing)C;T 2% T;T 97%
- Japanese (Tokyo)C;T <1% T;T 99%
- Yoruba (Nigeria)C;T <1% T;T 99%
- African ancestry (Southwest US)C;T 0% T;T 98%
- Maasai (Kenya)C;T 0% T;T 99%
- TuscanC;T 2% T;T 98%
Related
Conditions, medicines and genes
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293497A;Cconsidered a causal BRCA2 breast cancer mutationVery important
Notes
From SNPedia
Notes
aka c.8057T>C (p.Leu2686Pro) Classified as a BRCA2 gene pathogenic mutation for breast cancer based on likelihood cited in ClinVar and in
C;T
See details via ClinVar link on main SNP/rs# page.
Source and license
Adapted from rs28897746 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.