rs2854344
A SNP in the RB1 gene on chromosome 13. Its most notable genotype is A;A.
- Gene
- RB1
- Location
- Chr 1348,423,557 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 2%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedNo summary available.
- A;GNot ratedNo summary available.
- G;GGoodNo summary available.
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 7 HapMap populations.
- AverageA;A <1% A;G 3% G;G 97%
- European ancestry (Utah)A;A <1% A;G 12% G;G 88%
- Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
- Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
- Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
- Gujarati IndianA;A 0% A;G 3% G;G 97%
- Mexican ancestry (Los Angeles)A;A 0% A;G 2% G;G 98%
- TuscanA;A 0% A;G 3% G;G 97%
Related
Conditions, medicines and genes
Other RB1 SNPs
- rs3092891C;TRetinoblastoma (predicted)Very important
- rs121913296G;TRetinoblastoma (predicted)Very important
- rs121913300C;TRetinoblastoma (predicted)Very important
- rs121913301C;TRetinoblastoma (predicted)Very important
- rs121913302C;TRetinoblastoma (predicted)Very important
- rs121913303C;TRetinoblastoma (predicted)Very important
- rs121913304C;TRetinoblastoma (predicted)Very important
- rs121913305C;TRetinoblastoma (predicted)Very important
Notes
From SNPedia
Notes
associated with breast cancer risk and ovarian cancer More specifically: carriers of two rs2854344(A) alleles have a 25% reduced risk of developing ovarian cancer compared to carriers of two rs2854344(G) alleles, in a survey of ~5,000 women from the US, UK, and Denmark. showed no association with ovarian cancer risk 4,624 invasive epithelial ovarian cancer cases and 8,113 controls of white non-Hispanic origin ovarian cancer
Source and license
Adapted from rs2854344 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.